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BPN795: An Implantable Micro-Sensor for Cancer Surveillance

Project ID BPN795
Website
Start Date Thu 2015-Feb-05 19:57:26
Last Updated Sun 2017-Jan-29 16:57:27
Abstract We aim to develop a micro surveillance device for early identification of cancerous cell growth in collaboration with radiation oncology research from UCSF. UCSF will develop a molecular probe that specifically targets prostate specific membrane antigen (PSMA), which is over-expressed on prostate cancer cells. By radiolabelling these probes, cancer sites may be monitored in conjunction with an implantable array. We will design a 100x100 um semiconductor radiation sensor that can feasibly detect and localize cancer recurrence from 10^4 10^5 cells when placed near a cancer site. The sensors will use ultrasonic methods for power and signal transmission, as demonstrated in Dongjin et al, arXiv preprint arXiV:1307.2196 (2013). Initial sensor design will enhance CMOS device sensitivity to time dependent signal variation and will also explore signal recovery in the limited biological window where the radiolabelled probe is detectable.
Status Continuing
Funding Source BSAC Member Fees
IAB Research Area BioMEMS
Researcher(s) Stefanie V. Garcia
Advisor(s) Michel M. Maharbiz
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Summary Slide PDF | VIDEO
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