BERKELEY SENSOR & ACTUATOR CENTER
UC BERKELEY UC DAVIS
User: Guest |  Site Map |  My BSAC Profile
HOME  PROJECTS  THRUSTS  PUBLICATIONS  ABOUT BSAC  DIRECTORY  ALUMNI  FOR BSAC RESEARCHERS  EVENTS CALENDAR  SECURE LOGIN
Visiting Industrial Fellows
     
 
Dr. Jonghwan Lee

BioEngineering
Advisor: Prof. Lee

BIOGRAPHY

Integrated Multiplexed Optical Microfluidic System (iMOMs) for Dengue Diagnosis [BPN829]
Dengue is an endemic viral disease that affects tropical and subtropical areas. It is
estimated that more than 50 million infections occur worldwide per year. Due to its lack of
pathognomonic clinical features, dengue is often mistakenly diagnosed as other febrile diseases,
which thus leads to ineffective and costly overtreatment. Previously developed diagnostic tests for
dengue can only detect a single biomarker (or two to three kinds of targets) at a time and they
also lack comprehensive and syntagmatic analysis between various dengue-specific biomarkers. For an
effective and precision diagnostics of dengue infection, a diagnostic test should not only be
highly sensitive and specific, but also determine dengue virus serotype and distinguish between
primary and secondary infection. This can only be accomplished by developing a multiplexed test
that covers multiple targets. Here we present an integrated multiplexed optical microfluidic system
(iMOMs) with the detection capability of four different nucleic acids biomarkers and five different
protein biomarkers (i.e. NS-1, IgM, IgG, IgA, and IgE) on chip. We design, simulate, and fabricate
the iMOMs using polymer microfluidic substrates. We integrate biological printing technology with
the microfluidic device technology. We demonstrate multiplexed dengue specific- nucleic acid
amplifications and immunoassays. The iMOMs will be an ideal dengue diagnostic platform for both
developed and developing countries and can be applied to give accurate and ultra-sensitive point-of-
care diagnoses for other intractable diseases as well.


Current Active Projects:
BPN829
 

     Last Updated: Wed 2018-Feb-21 17:18:18

back to Researchers



 

  • Copyright Notification: All papers downloaded from this site are © University of California or the publisher, all rights reserved. Contact the BSAC Webmaster for permission related to copyrighted materials.
  • Links on these pages to commercial sites do not represent endorsements by UC or its affiliates.
  • Privacy Policy
  • Contact Us

   webmaster@bsac.eecs.berkeley.edu
  User logged in as: Guest
  User Idle since: February 22, 2018, 6:17 am