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Researchers
     
 
Rudra Mehta, B.S. 2018

Bioengineering
Advisor: Prof. Lin

BIOGRAPHY

Applications of 3D Printed Integrated Microfluidic Circuitry, Finger-Powered Pumps, and Mixers [BPN774]
In this ongoing project we have previously developed a new class of three-dimensional modular fluidic operators (i.e.
fluidic diodes, capacitors and transistors); passive 3D internally-rifled mixers; and have previously demonstrated low-
cost one-way pumping and mixing systems powered solely by the operatorís finger. Currently, we aim to develop our
easy-to-fabricate 3D microfluidic systems into functional biosensors via straight-forward integration with conductive
polymer electrodes. Here, we present our preliminary investigations into the development of entirely 3D printed
microfluidic salivary point-of-care diagnostic tools, specifically for the determination of salivary alcohol content (SAC)
and salivary lactate content (SLC). In law enforcement, blood alcohol content (BAC) is routinely determined indirectly
by measurement of breath alcohol content (BrAC) using commercialized breathalyzer technology. However,
measurement of SAC has a nearly 1:1 correlation with BAC, much closer than BAC:BrAC, over 2,000:1. Therefore, SAC
could prove to be a more reliable metric of sobriety than BrAC. In addition, for diabetic patients, continuous home
monitoring blood glucose levels necessitates repeated finger pricking and blood testing. However, researchers have
previously established measurable correlations between salivary lactic acid levels and blood glucose levels, opening
the possibility for non-invasive, point-of-care salivary-based blood sugar monitoring. In this project, we aim to
demonstrate proof-of-concept salivary diagnostic prototypes comprised of our previously-demonstrated 3D
microfluidic technology and composite conductive polymer electrodes. SAC will be determined via pH-sensitive
PEDOT:PSS/PANI polymer electrodes, and SLC will be determined via hydrogen peroxide-sensitive PEDOT:PSS/PAA
polymer electrodes. Upon further development, such designs could prove critical tools in resolving the foremost
commercial limitations of conventional microfluidic point-of-care diagnostic devices, specifically for salivary
diagnostics.


Current Active Projects:
BPN774
 

     Last Updated: Thu 2017-Aug-10 11:41:39

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